Computational Biology and Bioinformatics

Volume 7, Issue 2, December 2019

  • Discovering Gene Co-Expression Modules Using Fuzzified Adjusted Rand Index

    Taiwo Adigun, Angela Makolo

    Issue: Volume 7, Issue 2, December 2019
    Pages: 11-21
    Received: 20 May 2019
    Accepted: 24 June 2019
    Published: 6 August 2019
    Abstract: Understanding the interrelationship among genes in a cellular system is fundamental to the investigation of cellular activities, because the interrelated genes are either functionally related, controlled by the same transcriptional regulatory process or generally take part in a common biological process, and most importantly are known to be co-expr... Show More
  • Identification of a Novel Gene, Slc39a8, Encoding Zinc Transporter Specific to Treg Cells by Integrative Bioinformatic Analysis and Its Functional Validation

    Dong Woo Ko, Jeesang Yoon, Jung Jin Yang

    Issue: Volume 7, Issue 2, December 2019
    Pages: 22-29
    Received: 21 November 2019
    Accepted: 9 December 2019
    Published: 4 January 2020
    Abstract: Regulatory T cell (Treg cell) is a subset of T cell expressing Foxp3 transcription factor and critical for maintaining the immunological homeostasis in autoimmune micro-environment. However, the absence of the surface marker specific to Treg cell is the major barrier for the development of therapeutic reagent targeting Treg cells. To identify a nov... Show More