Computational Biology and Bioinformatics

Volume 2, Issue 2, April 2014

  • On the Investigation of Biological Phenomena through Computational Intelligence

    Jyotsana Pandey, B. K. Tripathi

    Issue: Volume 2, Issue 2, April 2014
    Pages: 19-24
    Received: 8 January 2014
    Accepted: 16 April 2014
    Published: 20 April 2014
    Abstract: This paper presents the approach towards understanding and building integrative system to explain biological phenomena like splicing, promoter gene identification, disease and disorder identification through artificial neural network based computational intelligence technique. Bioinformatics and computational intelligence are new research area whic... Show More
  • QSAR Studies, Design, Synthesis and Antimicrobial Evaluation of Azole Derivatives

    Vasyl Kovalishyn, Iryna Kopernyk, Svitlana Chumachenko, Oleg Shablykin, Kostyantyn Kondratyuk, Stepan Pil’o, Volodymyr Prokopenko, Volodymyr Brovarets, Larysa Metelytsia

    Issue: Volume 2, Issue 2, April 2014
    Pages: 25-32
    Received: 29 April 2014
    Accepted: 14 May 2014
    Published: 30 May 2014
    Abstract: QSAR analysis of a set of previously synthesized azole derivatives tested for growth inhibitory activity against Candida albicans was performed by using Associative Neural Network. To overcome the problem of overfitting due to descriptor selection, 5-fold cross-validation with variable selection in each step of the analysis was used. The predictive... Show More