Volume 5, Issue 6, December 2017, Page: 74-81
Prediction of Possible Effects of Arsenic and Cadmium in Human Health Using Chemical-Protein and Protein-Protein Interaction Network
Md. Taif Ali, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh
Md. Ashraful Alam, Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Md. Emdad Ullah, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh
Mohammad Arif Ashraf, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Japan
Md. Abu Sayed, Department of Biochemistry and Molecular Biology, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh
Aklima Jahan, Department of Chemistry, University of Chittagong, Chittagong, Bangladesh
Received: Jul. 10, 2017;       Accepted: Jul. 20, 2017;       Published: Nov. 28, 2017
DOI: 10.11648/j.cbb.20170506.11      View  2723      Downloads  184
Abstract
Arsenic and cadmium toxicity has demonstrated to be a crucial problem and there are many health issues interconnected with each other. The toxicity of these metals has no biological role even though remain present in some or the other form, hazardous for the human health and its proper functioning. As a result, from the very beginning, the researchers are trying to overcome the serious effects occurred by the heavy metals. The different procedures and methods are followed for minimizing the negative effects. The study was conducted to predict the probable effects and theirs targeted proteins in human body by recently developed advanced bioinformatics tools and subsequently found 10 proteins are interacted with arsenic and cadmium for each. However, these 10 proteins are independently associated with other 97 and 100 proteins. Finally, 25 common proteins have been identified which are affected by these two heavy metals. Our data mining search revealed that all of these 25 proteins are associated with the causing of cancer in human body.
Keywords
Arsenic, Cadmium, Cancer, Interaction, Heavy Metals, Human Health
To cite this article
Md. Taif Ali, Md. Ashraful Alam, Md. Emdad Ullah, Mohammad Arif Ashraf, Md. Abu Sayed, Aklima Jahan, Prediction of Possible Effects of Arsenic and Cadmium in Human Health Using Chemical-Protein and Protein-Protein Interaction Network, Computational Biology and Bioinformatics. Vol. 5, No. 6, 2017, pp. 74-81. doi: 10.11648/j.cbb.20170506.11
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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